Vampirella is now Queen of the Nosferatu and a member of The Kabal. Their job, hunt down and neutralize renegade monsters and fanatical cultists before they can trigger the Apocalypse. As a strange plague spreads through the slums of Sao Paolo, infecting its victims with homicidal fury, Vampirella pursues Dr. Faustus, the creator of the disease.
The best-selling author continues to redefine the horror heroine, bringing Vampi in as a new member of The Kabal, a clandestine organization of witches, werewolves, vampires, and other supernatural creatures who, like Hellboy's B.P.R.D., are trying to keep the word safe from their kind.
But the mad scientist is only one part in a global plot of destruction, and his fellow conspirators are perhaps too long-lived and powerful to defeat...